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apalutamide will minimize the extent or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medication which can be CYP3A4 substrates can lead to reduced exposure to those remedies.The regulation of modafinil as being a d